Shishani is a vocalist, guitarist and songwriter whose music transcends genres and cultures. During her career, Shishani has received multiple awards and nominations and has toured internationally. Her roots are Namibian and Belgian, but she grew up mainly in the Netherlands. Through her work, these worlds come together. She has performed internationally at Glastonbury Festival (UK), Afrika Festival Wurzburg (Germany), Amsterdam Roots Festival, Lake of Stars (Malawi) and various countries in almost all continents, including Europe, Africa, North America, and Asia.

Shishani is founder, producer, lead vocalist and songwriter of  the band Miss Catharsis (2019). An all-female group centralizing women of colour. She is also co-founder, lead vocalist and composer of Namibian Tales (2015), an acoustic quartet delving into the musical heritage of Namibia. With Namibian Tales, Shishani led an international project with UNESCO and the Museums Association of Namibia on safeguarding cultural heritage through archiving and producing new music in collaboration with San communities in Namibia. This project toured internationally. Shishani is also founder, vocalist and songwriter of Shakuar, a group combining live electronica with traditional instruments and enchanting voices, exploring artistic and spiritual expressions. In 2021, Shishani founded Sisterhood, a groupof 11 female artists who highlight a shared heritage between Indonesia and Namibia through the Dutch colonial past.